Viruses and other environmental factors as possible sources of phenotypic heterogeneity in familial dilated cardiomyopathy.

نویسندگان

  • Wolfgang Poller
  • Heinz-Peter Schultheiss
  • Uwe Kühl
چکیده

. Moreno PR, Fuster V. The year in atherothrombosis. J Am Coll Cardiol 2004;44:2099–110. . Muller JE, Stone PH, Turi ZG, et al. Circadian variation in the frequency of onset of acute myocardial infarction. N Engl J Med 1985; 313:1315–22. . Abo T, Kawate K, Itoh K, et al. Studies on the bioperiodicity of the immune response. Circadian rhythms of human T, B and K cell traffic in the peripheral blood. J Immunol 1981;126:1360–6. . Vernikos-Danellis J, Winget CM. The importance of light, postural and social cues in the regulation of the plasma cortisol rhythms in man. In: Reinberg A, Halberg F, editors. Chronopharmacology. New York, NY: Pergamon, 1979;101–6. . Millar-Craig MW, Bishop CN, Raftery EB. Circadian variation of blood pressure. Lancet 1978;1:795–7. . Panza JA, Epstein SE, Quyyumi AA. Circadian variation in vascular tone and its relation to -sympathetic vasoconstrictor activity. N Engl J Med 1991;325:986–90. . Huber K, Rosc D, Resch I, et al. Circadian fluctuations of plasminogen activator inhibitor and tissue plasminogen activator levels in plasma of patients with unstable coronary artery disease and acute myocardial infarction. Thromb Haemost 1988;60:372–6. . Domı́nguez-Rodriguez A, Abreu-Gonzalez P, Garcı́a-Gonzalez MJ, et al. Ritmo luz/oscuridad de las citocinas [proinflamatorias en el infarto agudo de miocardio]. Rev Esp Cardiol 2003;56:555–60. . Domı́nguez-Rodriguez A, Abreu-Gonzalez P, Garcı́a M, et al. Light/ dark patterns of interleukin-6 in relation to the pineal hormone melatonin in patients with acute myocardial infarction. Cytokine 2004;26:89–93.

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Familial dilated cardiomyopathy

Considerable progress has been made to identify genetic causation of dilated cardiomyopathy (DCM). DCM is characterized by left ventricular dilatation and systolic dysfunction, and after known causes have been excluded has been termed idiopathic dilated cardiomyopathy (IDC). Studies of IDC that occurs in families, termed familial dilated cardiomyopathy (FDC) provided the initial phenotypic data...

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Clinical and genetic issues in familial dilated cardiomyopathy.

Idiopathic dilated cardiomyopathy (IDC) is characterized by left ventricular dilatation and systolic dysfunction after known causes have been excluded. Idiopathic dilated cardiomyopathy occurring in families, or familial dilated cardiomyopathy (FDC), may occur in 20% to 50% of IDC cases. Sixteen genes have been shown to cause autosomal dominant FDC, but collectively may account for only a fract...

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The value of myocardial perfusion imaging in differentiating between idiopathic dilated cardiomyopathy from the ischemic form [Persian]

Introduction: Differentiating between ischemic cardiomyopathy (ICM) and idiopathic dilated cardiomyopathy (IDCM) is important as coronary revascularization can improve prognosis in the ischemic subgroup. Due to inherent problems of coronary angiography in patients with depressed ejection fraction (EF) introducing a noninvasive tool to diagnose those who will benefit from angiography seems...

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Massive pericardial effusion and dilated cardiomyopathy in a patient with familial multiple myeloma.

An 80-years-old-man with adult polycystic kidney disease and familial multiple myeloma that is complicated with massive pericardial effusion and dilated cardiomyopathy during the course of the disease is presented. Although no definite single genetic disorder is described, multiple myeloma cases may be seen in certain families. Environmental factors are also blamed in the etiology. Multiple mye...

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Whole exome sequencing identifies a KCNJ12 mutation as a cause of familial dilated cardiomyopathy

Dilated cardiomyopathy (DCM) is characterized by left ventricular dilation, and is associated with systolic dysfunction and increased action potential duration. Approximately 50% of DCM cases are caused by inherited gene mutations with genetic and phenotypic heterogeneity. Next generation sequencing may be useful in screening unknown mutations in such cases.A family was identified with DCM, in ...

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عنوان ژورنال:
  • Journal of the American College of Cardiology

دوره 47 3  شماره 

صفحات  -

تاریخ انتشار 2006